Course Syllabus

An introduction to human neuroimaging using magnetic resonance

PSYCH 204A | 3 units | UG Reqs: None | Class # 14950 | Section 01 | Grading: Letter or Credit/No Credit | SEM | Session: 2021-2022 Winter 1 | In Person
01/03/2022 - 03/11/2022 Tue, Thu 1:30 PM - 3:00 PM with Wandell, B. (PI); Kim, I. (TA)
Instructors: Wandell, B. (PI); Kim, I. (TA)
Classroom:  Building 300, Room 300 (map)

Magnetic resonance imaging (MRI) has become an important scientific tool for measuring living human brain structure and function. This course is for students who would like to learn the physical basis of MRI and how the method is used to make anatomical images of brain structures (sMRI and dMRI), measure quantitative tissue properties (qMRI), and assess brain activity (fMRI).

The course is designed to be helpful to people beginning to use MRI in their research and who would like to understand the strengths and limits of the methods when reading journal articles, listening to talks, or working with a collaborator. We aim to accommodate students from various backgrounds (e.g., engineering, neuroscience, psychology).  

This year the class lectures will be recorded and available online. We will also have regular meetings at the scheduled class time to discuss lecture material, talk over homework questions, and also talk over research papers of broad interest.  In the past, class discussions have been lively and I hope we can achieve the same interaction this year, which will at least partially be online!

The course work comprises a series of short homeworks (often including small programming examples and tutorials), and two longer homeworks that review the material in the first and then second half of the class.

This course leads naturally to Psych 204b.  

Course assistant:          Insub Kim (insubkim@stanford.edu)
Wandell office hours:   By appointment. Ask. Glad to meet. After class is usually a good time.
TA office hours with Insub: 4:30 pm to 5:30 pm on Mondays Zoom link here (pw:234861)

Textbook:     Huettel et al., FMRI (Third Edition, Oxford).  

Lecture recordings (previous years)

  • Lectures from a previous year (2017) are in the Panopto Section. 
  • New videos are being produced and will appear in Panopto folders and announced to the class.

Github sites for course tutorials and software (Matlab)

To download Matlab at no charge, follow these instructions.

00 Course Information (videos):

How to download the Matlab tutorials, navigate the Canvas page, and a course overview.  These are available view prior to the first lecture (1/4).

The schedule below lists the videos in the approximate time that you should watch them.  The online meetings will be devoted to discussing the videos from the prior lecture.  For example, on Thursday 1/6 we will discuss the general instrumentation videos.  I hope you understand that the complexity of navigating the online class under these circumstances will require some flexibility on all our parts.

Lecture Schedule (approximate)
Week/Day Date

Topic

Reading Homework Videos
1.1

1/4

Introduction: The Instrument 

Chapters 1
01 MR Physics

Link to GitHub repository with tutorials 

01 Instrument and MR terms 

MR Instrumentation playlist.

1.2 1/6

MR signals I
(Instrument, FID)
(01 MR Physics.pdf)

Chapter 2

02 MR Signals

MR Signals playlist 1 -6

 

2.1

1/11

MR signals II
(T1, T2, T2*)
(01 MR Physics.pdf)

Chapter  3 (Conceptual) 
01 MR Physics
(Slide 65 or so)

HW1 released

mrTut01_MR

 

02 MR Signals

MR Signals playlist 7 - 9

2.2 1/13

MR signals III
(Pulse sequences, BOLD contrast )
(01 MR Physics.pdf)

Chapter 4
(Conceptual)
01 MR Physics
(Slide 110 or so)

 

02 MR Signals

MR Signals playlist 10 -11

03 Image Formation
playlist 1-2

3.1 1/18

Image formation I
Linear Systems, Slice selection, K-space sampling
(02 MR Imaging.pdf)

Chapter 5
02 MR Imaging
Start slide 15ish

HW1 due 

HW2 released

mrTut02_Imaging 

03 Image Formation playlist 3 - 7

3.2 1/20

Image formation II
Pulse sequences, Parallel imaging, Image quality, Signal equations; identify sequences
(02 MR Imaging.pdf)

Chapter 5
(p. 147 et seq.)
Slide 60ish

03 Image Formation playlist 8 - 11
4.1 1/25

BOLD I 
The human brain parts
What do we want to measure?
History - Mosso, Fulton, Fox-Raichle; 
(03 BOLD.pdf)

Chapters 6, 7
Logothetis & Wandell; Boynton et al. 
Start at end  02 MR Imaging

HW2 due 

HW3 released

mrTut03_LinearSystems

04 BOLD Functional MRI playlist 1 - 5

4.2   1/27

BOLD  II
Vasculature
BOLD (fMRI) and electrophysiological measures
More history and some philosophy

Dumoulin and Wandell;

Wandell and Winawer

(Start at slide 25)

 

04 BOLD Functional MRI playlist 6 - 12

5.1 2/1

Computational neuroimaging, linearity tests, HRF
(04 Time Series, Statistics)

HW3 due 

MIDTERM released

05 Computational Neuroimaging playlist
BOLD -01 
and
Time Series 01

5.2 2/3

BOLD contrast
(04 Time Series, Statistics)

 

05 Computational Neuroimaging playlist
Time Series 02

6.1 2/8

Statistical reasoning
Hits, FA, ROC/AUC

 

MIDTERM must be completed by 11:59

HW4 released

Neuralink: 
Thinking big.

05 Computational Neuroimaging playlist
SDT 01, 02 

6.2 2/10 Visual field maps, PRFs

 

05 Computational Neuroimaging
Vision 01, 02

7.1 2/15

Diffusion Imaging: Principles and applications

Chapter 5
(p. 138 et seq.) 

HW4 due

mrTut04_Diffusion

06 Diffusion
01-05

7.2 2/17

Modeling diffusion data I –
Ball and stick, multiple tensors, multi-shell

Wandell review

06 Diffusion

06-10

8.1 2/22

Fiber tractography principles
Fascicle labeling (Tracula, AFQ)
Tractography evaluation (LiFE)

HW5 released

mrTut05_Visualization

 

07 Tractography

01-04

8.2 2/24

Quantitative MRI measures.
Proton density, Molecular Tissue Volume, T1, T2

Ensemble tractography
Diffusion Kurtosis Imaging

This one goes to 11.

07 Tractography

06 - Tractography as a model

08 Quantitative MRI 


  • Diffusion kurtosis imaging
  • Diffusion spectrum imaging
9.1 3/1

Topics in perception and memory

Wandell, Chial, Backus;
Pestilli self-potraits of the brain
Dale, Fischl & Sereno

HW5 due 

HW6 released

 

08 Quantitative MRI
Macromolecular tissue volume 1 and 2.

9.2 3/3

Potential topics:
Multi-echo measurements
NODDI
G-Ratio imaging

 

08 Quantitative MRI

  • Eddy Currents
  • Predicting vulnerability
10.1  3/8

Functional connectivity (resting state)


Readings to be determined

 

HW6 due 

 

08 Quantitative
Applications

09 Visualization and reproducibility

10.2 3/10  Data and computational management tools

 

Markus;
Calhoun;

You can't have enough of the big picture (1).

Big picture.  It's really big (2)

 

 

We discuss topics that came up in class that need more attention, or read a new paper or two.

09 Wrap up discussion

 Homework can be done over the course of a week. 

Discuss with others, but complete the homework (and exams) on your own.

The midterm must be completed during a 24 hour time period (of your choosing) within the week. 

Note: Grades are due 3/22. 

Course Summary:

Date Details Due